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This report reflects the consensus views and judgments of the committee members, based in part on consultation with experts from academia, major medical societies, relevant governmental agencies, and industry representatives. This study was supported by Contract No.

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Department of Energy and Contract No. Department of Health and Human Services. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author s and do not necessarily reflect the views of the organizations or agencies that provided support for the project. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

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